Variation in the purinergic P2RX(7) receptor gene and schizophrenia

Thomas F Hansen, Klaus D Jakobsen, Mogens Fenger, Jimmi Nielsen, Karoline Krane, Anders Fink-Jensen, Henrik Lublin, Henrik Ullum, Sally Timm, August G. Wang, Niklas Rye Jørgensen, Thomas Werge

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.
Original languageEnglish
Pages (from-to)146-152
Number of pages7
JournalSchizophrenia Research
Volume104
Issue number1-3
DOIs
Publication statusPublished - 2008

Keywords

  • adult
  • aged 80 and over
  • alleles
  • Denmark
  • european continental ancestry group
  • female
  • genetic variation
  • genotype
  • humans
  • male
  • middle aged
  • polymorphism
  • single nucleotide
  • receptors
  • purinergic P2
  • schizophrenia
  • young adult
  • P2XR7
  • Treatment resistance
  • Register data

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