Umbilical Cord Serum 25-Hydroxyvitamin D Concentrations and Relation to Birthweight, Head Circumference and Infant Length at Age 14 Days

Christine Dalgard, Maria Skaalum Petersen, Ulrike Steuerwald, Pál Weihe, Philippe Grandjean

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

BackgroundInsufficient supply of vitamin D during early development may negatively affect offspring growth. MethodsWe examined the association between umbilical cord (UC) serum 25-hydroxyvitamin D (25(OH)D) concentrations and infant size in a study of two Faroese birth cohorts of 1038 singleton infants. In the third trimester, the pregnant women completed questionnaires, and clinical examination included birthweight, head circumference, and infant length at age 14 days. ResultsFifty-three percent of the newborn population had UC 25(OH)D < 25 nmol/L as determined by LC-MS/MS. Using multiple linear regression models with adjustment for pre-pregnancy BMI, sex, parity, gestational age, or infant age at examination, season of birth, smoking, gestational diabetes, examiner, and cohort identity, we found no relationship between birthweight or head circumference and UC 25(OH)D. However, infants with vitamin D status 50 nmol/L in models further adjusted for birthweight. ConclusionOur data suggest that umbilical cord serum 25(OH)D concentrations are positively associated with infant length but not with birthweight and head circumference. Although the paediatric relevance of the observed association is unclear, the possible long-term consequences of late-pregnancy hypovitaminosis D deserve attention.
Original languageEnglish
Pages (from-to)238-245
Number of pages8
JournalPaediatric and Perinatal Epidemiology
Volume30
Issue number3
DOIs
Publication statusPublished - May 2016

Keywords

  • umbilical cord serum 25(OH)D
  • prenatal vitamin D exposure
  • birthweight
  • infant length
  • vitamin-D status
  • early-pregnancy
  • D deficiency
  • D level
  • fetal
  • outcomes
  • newborn
  • predictors
  • children
  • women

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