Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study

Erik G Jönsson, Kristina Larsson, Maria Vares, Thomas F Hansen, August G. Wang, Srdjan Djurovic, Kjersti S Rønningen, Ole A Andreassen, Ingrid Agartz, Thomas Werge, Lars Terenius, Håkan Hall

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case-control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case-control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia. Additional studies are warranted to shed further light on these relationships.
Original languageEnglish
Pages (from-to)976-982
Number of pages7
JournalAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume147B
Issue number6
DOIs
Publication statusPublished - 2008

Keywords

  • adult
  • aged
  • bipolar disorders
  • case-control studies
  • cohort studies
  • female
  • gene frequency
  • genotype
  • Linkage disequilibrium
  • male
  • meta-analysis as topic
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • middle aged
  • polymorphism
  • single nucleotide
  • schizophrenia

Fingerprint

Dive into the research topics of 'Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study'. Together they form a unique fingerprint.

Cite this