The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells

E. Rivedal, S.-O. Mikalsen, T. Sanner

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Okadaic acid is a potent non-phorbol ester mouse skin tumor promoter. Unlike the phorbol ester tumor promoters, okadaic acid is unable to promote the induction of morphological transformation in Syrian hamster embryo cell colonies. On the contrary, okadaic acid seems to counteract the effect of phorbol esters on transformation. Also unlike phorbol ester tumor promoters, okadaic acid does not inhibit intercellular communication, neither in primary hamster embryo cells, nor in the phorbol ester sensitive cell line BPNi. Furthermore, okadaic acid has no effect on the reoccurrence of communication following removal of 12-O-tetradecanoylphorbol-13-acetate.
Original languageEnglish
Pages (from-to)1302-1308
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume167
Issue number3
DOIs
Publication statusPublished - 1990
Externally publishedYes

Keywords

  • Okadaic acid
  • Diarrhetic shellfish poison
  • In vitro assays
  • gap junctional intercellular communication

Fingerprint

Dive into the research topics of 'The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells'. Together they form a unique fingerprint.

Cite this