Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

CAG Timmermann, E Budtz-Jorgensen, MS Petersen, P Weihe, U Steuerwald, F Nielsen, TK Jensen, P Grandjean

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed. In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding. (C) 2016 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalReproductive Toxicology
Volume68
DOIs
Publication statusPublished - Mar 2017

Keywords

  • breast milk
  • breastfeeding
  • endocrine disruption
  • lactation
  • maternal health
  • perfluoroalkyl substances
  • mammary-gland development
  • perfluorooctanoic acid
  • serum concentrations
  • pregnancy
  • growth
  • predictors
  • children
  • women
  • PFOA

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