Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene

Mirjana Tosic, Jurg Ott, Sandra Barral, Pierre Bovet, Patricia Deppen, Fulvia Gheorghita, Marie-Louise Matthey, Josef Parnas, Martin Preisig, Michael Saraga, Alessandra Solida, Sally Timm, August G. Wang, Thomas Werge, Michel Cuénod, Kim Quang Do

Research output: Contribution to journalArticlepeer-review

192 Citations (Scopus)

Abstract

Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
Original languageEnglish
Pages (from-to)586-592
Number of pages7
JournalAmerican Journal of Human Genetics
Volume79
Issue number3
DOIs
Publication statusPublished - 1 Sep 2006

Keywords

  • schizophrenia
  • oxidative stress
  • GSH-synthesizing enzyme

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