Potassium kinetics in human muscle interstitium during repeated intense exercise in relation to fatigue

Magni Mohr, Nikolai Nordsborg, Jens Jung Nielsen, Lasse Danneman Pedersen, Christian Fischer, Peter Krustrup, Jens Bangsbo

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

Accumulation of K+ in skeletal muscle interstitium during intense exercise has been suggested to cause fatigue in humans. The present study examined interstitial K+ kinetics and fatigue during repeated, intense, exhaustive exercise in human skeletal muscle. Ten subjects performed three repeated, intense (61.6±4.1 W; mean±SEM), one-legged knee extension exercise bouts (EX1, EX2 and EX3) to exhaustion separated by 10-min recovery periods. Interstitial [K+] ([K+]interst) in the vastus lateralis muscle were determined using microdialysis. Time-to-fatigue decreased progressively (P
Original languageEnglish
Pages (from-to)452-456
Number of pages5
JournalPflügers Archiv: European Journal of Physiology
Volume448
DOIs
Publication statusPublished - 27 Mar 2004

Keywords

  • intermittent exercise
  • anaerobic metabolism
  • K_atp channels
  • muscle acidosis
  • microdialysis

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