Physical Activity and Sedentary Behaviors Associated With Risk of Progression From Gestational Diabetes Mellitus to Type 2 Diabetes Mellitus: A Prospective Cohort Study

W Bao, DK Tobias, K Bowers, J Chavarro, A Vaag, LG Grunnet, M Strom, J Mills, AY Liu, M Kiely, CL Zhang

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104 Citations (Scopus)

Abstract

Importance:
Women with a history of gestational diabetes mellitus (GDM) are at substantially increased risk of type 2 diabetes mellitus (T2DM). The identification of important modifiable factors could help prevent T2DM in this high-risk population.

Objective:
To examine the role of physical activity and television watching and other sedentary behaviors, and changes in these behaviors in the progression from GDM to T2DM.

Design, Setting, and Participants:
Prospective cohort study of 4554 women from the Nurses’ Health Study II who had a history of GDM, as part of the ongoing Diabetes & Women’s Health Study. These women were followed up from 1991 to 2007.

Exposures:
Physical activity and television watching and other sedentary behaviors were assessed in 1991, 1997, 2001, and 2005.

Main Outcomes and Measure:
Incident T2DM identified through self-report and confirmed by supplemental questionnaires.

Results:
We documented 635 incident T2DM cases during 59 287 person-years of follow-up. Each 5–metabolic equivalent hours per week (MET-h/wk) increment of total physical activity, which is equivalent to 100 minutes per week of moderate-intensity physical activity, was related to a 9% lower risk of T2DM (adjusted relative risk [RR], 0.91; 95% CI, 0.88-0.94); this inverse association remained significant after additional adjustment for body mass index (BMI). Moreover, an increase in physical activity was associated with a lower risk of developing T2DM. Compared with women who maintained their total physical activity levels, women who increased their total physical activity levels by 7.5 MET-h/wk or more (equivalent to 150 minutes per week of moderate-intensity physical activity) had a 47% lower risk of T2DM (RR, 0.53; 95% CI, 0.38-0.75); the association remained significant after additional adjustment for BMI. The multivariable adjusted RRs (95% CIs) for T2DM associated with television watching of 0 to 5, 6 to 10, 11 to 20, and 20 or more hours per week were 1 (reference), 1.28 (1.04-1.59), 1.41 (1.11-1.79), and 1.77 (1.28-2.45), respectively (P value for trend <.001); additional adjustment for BMI attenuated the association.

Conclusions and Relevance:
Increasing physical activity may lower the risk of progression from GDM to T2DM. These findings suggest a hopeful message to women with a history of GDM, although they are at exceptionally high risk for T2DM, promoting an active lifestyle may lower the risk.

Original languageEnglish
Pages (from-to)1047-1055
Number of pages9
JournalJAMA INTERNAL MEDICINE
Volume174
Issue number7
DOIs
Publication statusPublished - 2014

Keywords

  • gestational diabetes mellitus
  • type 2 diabetes mellitus
  • physical activity

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