PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER

AG Vang, SZ Ben-Sasson, H Dong, B Kream, MP DeNinno, MM Claffey, W Housley, RB Clark, PM Epstein, S Brocke

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)
19 Downloads (Pure)

Abstract

Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs) is a prerequisite for effector T (Teff) cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell activation has been shown to induce PDE8, a PDE isoform with 40- to 100-fold greater affinity for cAMP than PDE4. Thus, we postulated that PDE8 is an important regulator of Teff cell functions.
Original languageEnglish
Pages (from-to)1-13
JournalPloS one
Volume5
Issue number8
DOIs
Publication statusPublished - Aug 2010

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