Moderate alcohol intake during pregnancy and the risk of stillbirth and death in the first year of life

Ulrik Kesmodel, Kirsten Wisborg, Sjúrður Fróði Olsen, Tine Brink Henriksen, Niels Jørgen Secher

Research output: Contribution to journalArticlepeer-review

163 Citations (Scopus)

Abstract

The authors evaluated the association between alcohol intake during pregnancy and risk of stillbirth and infant death in a cohort of pregnant women receiving routine antenatal care at Aarhus University Hospital (Aarhus, Denmark) between 1989 and 1996. Prospective information on alcohol intake, other lifestyle factors, maternal characteristics, and obstetric risk factors was obtained from self-administered questionnaires and hospital files, and 24,768 singleton pregnancies were included in the analyses (116 stillbirths, 119 infant deaths). The risk ratio for stillbirth among women who consumed > or =5 drinks/week during pregnancy was 2.96 (95% confidence interval: 1.37, 6.41) as compared with women who consumed or = 5 drinks/week. The increased risk could not be attributed to the effect of alcohol on the risk of low birth weight, preterm delivery, or malformations. There was little if any association between alcohol intake and infant death.
Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalAmerican journal of Epidemiology
Volume155
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • Adult
  • Alcohol Drinking/adverse effects
  • Cohort Studies
  • Epidemiologic Studies
  • Female
  • Fetal Death/etiology
  • Humans
  • Infant Mortality
  • Infant, Newborn
  • Life Style
  • Maternal-Fetal Exchange
  • Odds Ratio
  • Pregnancy
  • Pregnancy Complications/etiology
  • Prospective Studies
  • Risk Factors

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