Maternal fish oil supplementation in lactation: effect on visual acuity and n-3 fatty acid content of infant erythrocytes

Lotte Lauritzen, M. H. Jørgensen, T. B. Mikkelsen, Ib Michael Skovgaard, E. M. Straarup, S. F. Olsen, C. E. Høy, Kim Fleischer Michaelsen

Research output: Contribution to journalArticlepeer-review

114 Citations (Scopus)

Abstract

Studies on formula-fed infants indicate a beneficial effect of dietary DHA on visual acuity. Cross-sectional studies have shown an association between breast-milk DHA levels and visual acuity in breast-fed infants. The objective in this study was to evaluate the biochemical and functional effects of fish oil (FO) supplements in lactating mothers. In this double-blinded randomized trial, Danish mothers with habitual fish intake below the 50th percentile of the Danish National Birth Cohort were randomized to microencapsulated FO [1.3 g/d long-chain n−3 FA (n−3 LCPUFA)] or olive oil (OO). The intervention started within a week after delivery and lasted 4 mon. Mothers with habitual high fish intake and their infants were included as a reference group. Ninety-seven infants completed the trial (44 OO-group, 53 FO-group) and 47 reference infants were followed up. The primary outcome measures were: DHA content of milk samples (0, 2, and 4 mon postnatal) and of infant red blood cell (RBC) membranes (4 mon postnatal), and infant visual acuity (measured by swept visual evoked potential at 2 and 4 mon of age). FO supplementation gave rise to a threefold increase in the DHA content of the 4-mon milk samples (P
Original languageEnglish
Pages (from-to)195-206
Number of pages12
JournalLipids
Volume39
Issue number3
DOIs
Publication statusPublished - 1 Mar 2004

Keywords

  • BMI
  • DNBC
  • FA%
  • FFQ
  • fish oil supplementation (FOS)
  • HF-GROUP
  • LCPUFA
  • logMAR
  • MUFA
  • OO
  • RBC
  • SFA
  • SWEEP-VEP
  • VEP
  • infants

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