Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes

Freja Bach Kampmann, Anne Cathrine Baun Thuesen, Line Hjort, Anne Ahrendt Bjerregaard, Jorge Chavarro, Jan Frystyk, Mette Bjerre, Inge Tetens, Sjurdur F Olsen, Allan Vaag, Peter Damm, Louise Groth Grunnet

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Objective: Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponectin, and FGF21 concentrations and their associations with measures of adiposity and metabolic traits during childhood/adolescence.Design and Methods: The follow-up study included 504 GDM and 540 control offspring aged 9-16 from the Danish National Birth Cohort. Anthropometric measurements, fasting blood samples, puberty status and fat percentages by Dual-energy x-ray absorptiometry were examined. Serum concentrations of leptin, adiponectin, and FGF21 were measured by validated immune assays.Results: GDM offspring had 38% (95% CI: 22-55%) higher leptin, 0.6mg/L (95% CI -1.2, -0.04mg/L) lower adiponectin, and 32% (95% CI: -47%, -12%) lower FGF21 concentrations than control offspring (p
Original languageEnglish
Pages (from-to)691-700
Number of pages10
JournalEuropean journal of endocrinology
Volume181
Issue number6
DOIs
Publication statusPublished - 2019

Keywords

  • Adiponectin
  • Adiposity
  • Developmental programming
  • Fibroblast growth factor 21
  • Gestational diabetes mellitus
  • Leptin
  • Offspring metabolic health

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