Brain expressed microRNAs implicated in schizophrenia etiology

Thomas F Hansen; Line Olsen; Morten Lindow; Klaus D Jakobsen; Henrik Ullum; Erik Jonsson; Ole A Andreassen; Srdjan Djurovic; Ingrid Melle; Ingrid Agartz; Håkan Hall; Sally Timm; August G. Wang; Thomas Werge

doi:10.1371/journal.pone.0000873

Brain expressed microRNAs implicated in schizophrenia etiology

Thomas F Hansen, Line Olsen, Morten Lindow, Klaus D Jakobsen, Henrik Ullum, Erik Jonsson, Ole A Andreassen, Srdjan Djurovic, Ingrid Melle, Ingrid Agartz, Håkan Hall, Sally Timm, August G. Wang, Thomas Werge

Deildin fyri heilsu- og sjúkrarøktarvísindi - Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

221 Citations (Scopus)

2 Downloads (Pure)

Abstract

Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors. Indeed, the growing understanding of the regulatory properties and pleiotropic effects that miRNA have on molecular and cellular mechanisms, suggests that alterations in the interactions between miRNAs and their mRNA targets may contribute to phenotypic variation.

Original language	English
Number of pages	7
Journal	P L o S One
Volume	2
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0000873
Publication status	Published - 2007

Keywords

adult
case-control studies
Denmark
female
genotype
humans
male
microRNAs
middle aged
Norway
schizophrenia
Sweden

Access to Document

10.1371/journal.pone.0000873Licence: CC BY

Link to PDFFinal published version, 128 KBLicence: CC BY

Cite this

@article{d1c79a06477d449faa98594243783cd1,

title = "Brain expressed microRNAs implicated in schizophrenia etiology",

abstract = "Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors. Indeed, the growing understanding of the regulatory properties and pleiotropic effects that miRNA have on molecular and cellular mechanisms, suggests that alterations in the interactions between miRNAs and their mRNA targets may contribute to phenotypic variation.",

keywords = "adult, case-control studies, Denmark, female, genotype, humans, male, microRNAs, middle aged, Norway, schizophrenia, Sweden",

author = "Hansen, {Thomas F} and Line Olsen and Morten Lindow and Jakobsen, {Klaus D} and Henrik Ullum and Erik Jonsson and Andreassen, {Ole A} and Srdjan Djurovic and Ingrid Melle and Ingrid Agartz and H{\aa}kan Hall and Sally Timm and Wang, {August G.} and Thomas Werge",

year = "2007",

doi = "10.1371/journal.pone.0000873",

language = "English",

volume = "2",

journal = "P L o S One",

number = "9",

}

TY - JOUR

T1 - Brain expressed microRNAs implicated in schizophrenia etiology

AU - Hansen, Thomas F

AU - Olsen, Line

AU - Lindow, Morten

AU - Jakobsen, Klaus D

AU - Ullum, Henrik

AU - Jonsson, Erik

AU - Andreassen, Ole A

AU - Djurovic, Srdjan

AU - Melle, Ingrid

AU - Agartz, Ingrid

AU - Hall, Håkan

AU - Timm, Sally

AU - Wang, August G.

AU - Werge, Thomas

PY - 2007

Y1 - 2007

N2 - Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors. Indeed, the growing understanding of the regulatory properties and pleiotropic effects that miRNA have on molecular and cellular mechanisms, suggests that alterations in the interactions between miRNAs and their mRNA targets may contribute to phenotypic variation.

AB - Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors. Indeed, the growing understanding of the regulatory properties and pleiotropic effects that miRNA have on molecular and cellular mechanisms, suggests that alterations in the interactions between miRNAs and their mRNA targets may contribute to phenotypic variation.

KW - adult

KW - case-control studies

KW - Denmark

KW - female

KW - genotype

KW - humans

KW - male

KW - microRNAs

KW - middle aged

KW - Norway

KW - schizophrenia

KW - Sweden

UR - https://research.regionh.dk/en/publications/brain-expressed-micrornas-implicated-in-schizophrenia-etiology(d6ea99f7-f6ff-4919-9030-032f9fc89985).html

U2 - 10.1371/journal.pone.0000873

DO - 10.1371/journal.pone.0000873

M3 - Article

C2 - 17849003

VL - 2

JO - P L o S One

JF - P L o S One

IS - 9

ER -

Brain expressed microRNAs implicated in schizophrenia etiology

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this