Brain expressed microRNAs implicated in schizophrenia etiology

Thomas F Hansen, Line Olsen, Morten Lindow, Klaus D Jakobsen, Henrik Ullum, Erik Jonsson, Ole A Andreassen, Srdjan Djurovic, Ingrid Melle, Ingrid Agartz, Håkan Hall, Sally Timm, August G. Wang, Thomas Werge

Research output: Contribution to journalArticlepeer-review

218 Citations (Scopus)

Abstract

Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors. Indeed, the growing understanding of the regulatory properties and pleiotropic effects that miRNA have on molecular and cellular mechanisms, suggests that alterations in the interactions between miRNAs and their mRNA targets may contribute to phenotypic variation.
Original languageEnglish
Number of pages7
JournalP L o S One
Volume2
Issue number9
DOIs
Publication statusPublished - 2007

Keywords

  • adult
  • case-control studies
  • Denmark
  • female
  • genotype
  • humans
  • male
  • microRNAs
  • middle aged
  • Norway
  • schizophrenia
  • Sweden

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