Benchmark dose calculations of methylmercury-associated neurobehavioural deficits

Esben Budtz-Jørgensen, Philippe Grandjean, Niels Keiding, Roberta F. White, Pal Weihe

    Research output: Contribution to journalArticlepeer-review

    67 Citations (Scopus)


    Prenatal methylmercury exposure is associated with neuropsychological deficits in Faroese children at age 7 years. Lower confidence bounds of benchmark doses (BMDLs) have now been calculated. With the cord-blood mercury concentration as the dose parameter, a logarithmic dose-response model tended to show a better fit than a linear dose model for the attention, language and verbal memory tests. The lowest BMDLs averaged ~5 μg/l cord blood, which corresponds to a maternal hair concentration of ~1 μg/g. However, most BMDLs for hair mercury concentrations were higher. Thus, the results of the benchmark calculations depend on the assumed dose-response model. Copyright (C) 2000 Elsevier Science Ireland Ltd.
    Original languageEnglish
    Pages (from-to)193-199
    Number of pages7
    JournalToxicology Letters
    Publication statusPublished - 15 Mar 2000


    • Food contamination
    • Prenatal exposure delayed effects
    • Risk assessment


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